Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System

Introduction: AQP4 (aquaporin-4)–immunoglobulin G (IgG)-mediated neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that affects the central nervous system, particularly spinal cord and optic nerve; remyelination capacity in yet to be determined, as role of AQP4–IgG cell differentiation. Material Methods: We included three groups—a group patients with AQP4–IgG-positive optica, a healthy group, sham group. analyzed differentiation cultures neurospheres from subventricular zone mice by adding serum at two different times: early advanced stages also into lines. Results Conclusions: The effect sera NMOSD on precursor cells differs according degree differentiation, probably oligodendrocyte progenitor NG2 lesser extent than zone; however, resulting oligodendrocytes may compromised terms maturation possibly limited their ability generate myelin. Furthermore, these decrease number age. It very unlikely use drugs favoring migration multiple sclerosis would effective context but therapy seems potential alternative.